Issue 2, 1978

Chromenylation of 2-naphthol and alkylhydroquinones: short syntheses of (2RS,4′R,8′R)-α-tocopherol (vitamin E) and (2RS,4′R,8′R)-β-tocopherol

Abstract

Chromenylation of alkylhydroquinones (and 2-naphthol) can be effected by heating aryloxymagnesium bromides with α-unsaturated acetals in benzene thus providing short and simple syntheses of α- and β-tocopherol and a prenylogue of α-tocotrienol.

Article information

Article type
Paper

J. Chem. Soc., Chem. Commun., 1978, 59-60

Chromenylation of 2-naphthol and alkylhydroquinones: short syntheses of (2RS,4′R,8′R)-α-tocopherol (vitamin E) and (2RS,4′R,8′R)-β-tocopherol

J. O. Asgill, L. Crombie and D. A. Whiting, J. Chem. Soc., Chem. Commun., 1978, 59 DOI: 10.1039/C39780000059

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