The chymotrypsin-catalysed hydrolyses of a number of substituted aryl acetates have been studied. For all the esters with poorer leaving groups the reactions obey simple first-order kinetics. Esters with a 4-nitro-group show ‘burst’ kinetics but this is not the case for esters with equally good leaving groups but no 4-nitro-group. This distinction does not occur when pyridine is the catalyst.
A. R. Butler, I. H. Robertson and L. A. Rudkin, J. Chem. Soc., Perkin Trans. 2, 1977, 351 DOI: 10.1039/P29770000351
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