Promotion of the catalytic hydrogenation of phthalimide and substituted phthalimides over palladium
Abstract
Phthalimide undergoes quantitative conversion into isoindolin-1-one (3c) upon hydrogenation in ethyl acetate over 10% palladium–carbon in the presence of trifluoroacetic acid, but resists reduction in its absence. This reaction is also promoted by iron(II) sulphate. The effect of N- and ring-substitution on the trifluoroacetic acid-promoted reduction has been investigated.