Issue 18, 1977

Synthesis of analogues of bradykinin with replacement of the arginine residues by 4-guanidinophenyl-L-alanine

Abstract

The synthesis is described of three analogues of bradykmin in which the terminal arginine residues were separately or together replaced by 4-guanidinophenyl-L-alanine. The analogues were considerably less potent than the parent peptide in their action on smooth muscle in vitro

Article information

Article type
Paper

J. Chem. Soc., Perkin Trans. 1, 1977, 2025-2030

Synthesis of analogues of bradykinin with replacement of the arginine residues by 4-guanidinophenyl-L-alanine

S. Moore, H. D. Law, D. E. Brundish, D. F. Elliott and R. Wade, J. Chem. Soc., Perkin Trans. 1, 1977, 2025 DOI: 10.1039/P19770002025

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