Synthesis of isoquinoline derivatives related to the endo-6,14-ethenotetrahydrothebaines. Part 2

Abstract

A series of secondary and tertiary alcohols have been prepared by the action of Grignard reagents on exo- and endo-7-acetyl-1,2,3,4,6,7,8,8a-octahydro-6-methoxy-2-methyl-6,8a-ethanoisoquinolines and on exo- and endo-6-acetyl-1,2,3,4,4a,5,6,7-octahydro-7-methoxy-2-methyl-4a,7-ethanoisoquinolines. Structures have been assigned to these on the basis of their n.m.r. and i.r. spectra and the analgetic activity of the compounds is described.