Synthesis of derivatives of methyl 2,6-dideoxy-4-O-methyl-α-D-ribo-hexopyranoside: on the structure of variose
Abstract
Methyl 3-O-benzoyl-2,6-dideoxy-4-O-methyl-α-D-ribo-hexopyranoside (10) has been synthesised by an unambiguous route from methyl 4,6-O-benzylidene-2-deoxy-α-D-ribo-hexopyranoside (2). The benzoate (10) differs from benzoylated methyl varioside (obtained by way of methanolysis of the antibiotic variamycin), which is claimed to have the same structure.