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Issue 5, 1977
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Absolute configuration of 2,3-dihydroxy-3-methylpentanoic acid, an intermediate in the biosynthesis of isoleucine, and its identity with the esterifying acid of the pyrrolizidine alkaloid strigosine

Abstract

The (–)-erythro- and (–)-threo-isomers of 2,3-dihydroxy-3-methylpentanoicacid (I) have been synthesised. The (–)-erythro-isomer has been shown to have the absolute configuration 2R,3R and to be identical with the naturally occurring (–)-acid, a precursor of isoloucine (II), and with the esterifying acid of the pyrrolizidine alkaloid Strigosine.

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J. Chem. Soc., Perkin Trans. 1, 1977, 544-549
Article type
Paper

Absolute configuration of 2,3-dihydroxy-3-methylpentanoic acid, an intermediate in the biosynthesis of isoleucine, and its identity with the esterifying acid of the pyrrolizidine alkaloid strigosine

D. H. G. Crout and D. Whitehouse, J. Chem. Soc., Perkin Trans. 1, 1977, 544
DOI: 10.1039/P19770000544

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