Studies on the syntheses of heterocyclic compounds. Part 680. Abnormal formation of aporphine derivatives by Grewe cyclisation
Abstract
Grewe cyclisation of 1,2,3,4,5,8-hexahydro-1-(4-hydroxybenzyl)-2-methylisoquinoline (5) under various conditions gave the aporphines (11), (12), and (14): the structures of (11) and (12) were confirmed by alternative syntheses.