The major product of the reaction of tetracycline hydrochloride with N-chlorosuccinimide has been shown by spectroscopic and X-ray analysis to be the novel bridged tetracycline derivative (3).
D. H. R. Barton, S. V. Ley, K. Meguro and D. J. Williams, J. Chem. Soc., Chem. Commun., 1977, 790 DOI: 10.1039/C39770000790
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