Issue 20, 1977

Synthesis of prostaglandin-F by conjugate addition of a cuprate reagent to 3-t-butyldimethylsilyloxytricyclo[3.2.0.02,7]heptan-6-one

Abstract

A novel synthesis of (±)-prostaglandin-F involves the stereospecific formation of 3-endo-t-butyldimethylsiloxytricyclo[3.2.0.02,7]heptan-6-one (3) and reaction of this strained cyclopropyl ketone with the organocuprate reagent (4).

Article information

Article type
Paper

J. Chem. Soc., Chem. Commun., 1977, 716-716

Synthesis of prostaglandin-F by conjugate addition of a cuprate reagent to 3-t-butyldimethylsilyloxytricyclo[3.2.0.02,7]heptan-6-one

M. J. Dimsdale, R. F. Newton, D. K. Rainey, C. F. Webb, T. V. Lee and S. M. Roberts, J. Chem. Soc., Chem. Commun., 1977, 716 DOI: 10.1039/C39770000716

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