Issue 13, 1977

Conversion of guanosine into its N2-methyl derivative

Abstract

N 2 -Methylguanosine (1c) may be prepared in satisfactory yield by treating the protected guanosine derivative (5a) with diazomethane and then removing the protecting groups; (5a), which readily reacts with dimethylamine to give (5c), may be prepared from (4a) in good yield.

Article information

Article type
Paper

J. Chem. Soc., Chem. Commun., 1977, 447-448

Conversion of guanosine into its N2-methyl derivative

P. K. Bridson, W. Markiewicz and C. B. Reese, J. Chem. Soc., Chem. Commun., 1977, 447 DOI: 10.1039/C39770000447

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