Use of the silver electrode in the potentiometric determination of quaternary ammonium compounds

Abstract

A reduced-scale direct potentiometric titration method is proposed for determining medicinally important quaternary ammonium compounds alone or in pharmaceutical formulations. An automatic titrator is employed with a silver-mercury(I) sulphate electrode system. The procedure reported provides a precise, accurate and rapid analysis when 0.03–0.13 g l^–1 of compound is present in aqueous solution.