Evidence is presented consistent with a lipophilic binding site for the leaving group and for the alkyl or aromatic function of the acylamino-group in specific substrates of α-chymotrypsin. Binding of small, non-specific substrates and inhibitors to α-chymotrypsin is shown, by comparison with elastase, to involve at the most only a small fraction of the ‘ tosyl-hole. ’
J. Udris and A. Williams, J. Chem. Soc., Perkin Trans. 2, 1976, 686 DOI: 10.1039/P29760000686
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