Several polycyclic β-lactams have been synthesized by the reactions of cyclic imines with acid chlorides in the presence of triethylamine. The azido-functions in these β-lactams were reduced to amino-groups, which were then acylated with phenylacetyl chloride to introduce the penicillin G side chain. Some carbocyclic analogues of cephalosporin were found to possess antibacterial activity.
A. K. Bose, S. G. Amin, J. C. Kapur and M. S. Manhas, J. Chem. Soc., Perkin Trans. 1, 1976, 2193 DOI: 10.1039/P19760002193
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