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Issue 11, 1976
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A one-step synthesis of the phthalidylisoquinoline alkaloids, cordrastine and hydrastine

Abstract

Cordrastine (5a) and hydrastine (5b) were synthesised by condensation of 3,4-dihydro-6,7-dimethoxy-2-methyl-(1a) and 3,4-dihydro-6,7-methylenedioxy-2-methyl-isoquinolinium (1b) salts, respectively, with methyl 6-diazomethyl-2,3-dimethoxybenzoate (2a) derived from 6,7-dimethoxyphthalimidine (16a). The reaction of (1a) with methyl 2-diazomethyl-4,5-dimethoxybenzoate (2b) gave the cordrastine isomer (5c).

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Article information


J. Chem. Soc., Perkin Trans. 1, 1976, 1221-1225
Article type
Paper

A one-step synthesis of the phthalidylisoquinoline alkaloids, cordrastine and hydrastine

T. Kametani, T. Honda, H. Inoue and K. Fukumoto, J. Chem. Soc., Perkin Trans. 1, 1976, 1221
DOI: 10.1039/P19760001221

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