Fungal products. Part XVIII. 13C nuclear magnetic resonance spectrum and biosynthesis of colletodiol

Abstract

In the ¹³C n.m.r. spectrum of colletodiol (10,11-dihydroxy-2,8-dimethyl-1,7-dioxacyclotetradeca-4,12-diene-6,14-dione)(1), the resonances have been assigned by correlation with ¹H n.m.r. assignments from irradiation experiments at single frequencies in the range of proton resonances. Spectra of colletodiol derived by incorporation of [1-¹³C]- and [2-¹³C]-acetate showed ¹³C enrichments consistent with a biosynthetic pathway from the union of a triketide and a tetraketide component.