The reaction of allyltrimethylsilane with α-keto esters in the presence of titanium tetrachloride afforded a γδ-unsaturated α-hydroxyvalerate in high yield, which with chiral α-keto esters in asymmetric synthesis gave 16–55% enantiomeric excess product.
I. Ojima, Y. Miyazawa and M. Kumagai, J. Chem. Soc., Chem. Commun., 1976, 927 DOI: 10.1039/C39760000927
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