Issue 1208, 1976

Determination of triamcinolone acetonide in cream and suspension formulations by high-performance liquid chromatography

Abstract

Methods are described for the determination of triamcinolone acetonide at concentrations of 0.025 and 0.1%m/m in creams and 2 and 6 mg ml–1 in suspensions. Triamcinolone acetonide extracted from these formulations is assayed by high-performance liquid chromatography, using a reversed-phase separation on a Spherisorb S10 ODS column with a solvent system of methanol and water. Prednisolone is used as an internal standard.

The main advantages of the method are the over-all speed of analysis and the degree of precision obtained.

Article information

Article type
Paper

Analyst, 1976,101, 876-882

Determination of triamcinolone acetonide in cream and suspension formulations by high-performance liquid chromatography

G. Gordon and P. R. Wood, Analyst, 1976, 101, 876 DOI: 10.1039/AN9760100876

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