Preparation of some fluoropalmitic acids and fluorination of brefeldin A
Abstract
Syntheses of 6-, 7-, 13-, and 16-fluoropalmitic acid are described. Treatment of brefeldin A (1) with 2-chloro-NN-diethyl-1,1,2-trifluoroethylamine afforded the difluorodideoxybrefeldin A (3).