Synthesis of 3-alkyl-1-aryl-6,7-dihydro-6,6-dimethylindazol-4(5H)-ones, 2,3-diaryl-4,5,6,7-tetrahydroindazoles, and related compounds
Abstract
1,2-Dimethyl-7a-hydroxy-4-oxo-1,4,5,6,7,7a-hexahydroindazole hydrochloride (I) was obtained in moderate yield from cyclohexane-1,3-dione, formaldehyde, and NN′-dimethylhydrazine. 3-Alkyl-1-aryl-6,7-dihydro-6,6-dimethylindazol-4(5H)-ones (VII) were prepared from 2-acyl-5,5-dimethylcyclohexane-1,3-diones and arylhydrazines. 2,3-Diaryl-4,5,6,7-tetrahydroindazoles (XI) resulted from the reaction of 3′-arylspiro[cyclohexane-2′-oxiran]-2-ones with arylhydrazines.