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Issue 19, 1975
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Synthesis of 18-substituted steroids. Part I. 18,21-Dihydroxypregn-4-ene-3,20-dione (18-hydroxydeoxycorticosterone)

Abstract

The reaction between an 18-hydroxypregnan-20-one [in the hemiacetal form (1b)] and lead tetra-acetate gives the 21-acetoxy-derivative in high yield, opening the way to a new and efficient synthesis of 18-hydroxydeoxycorticosterone. The preparation of the 1,2-didehydro-derivative of 18-hydroxydeoxycorticosterone is also described.

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Article type: Paper
DOI: 10.1039/P19750001860
J. Chem. Soc., Perkin Trans. 1, 1975, 1860-1864

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    Synthesis of 18-substituted steroids. Part I. 18,21-Dihydroxypregn-4-ene-3,20-dione (18-hydroxydeoxycorticosterone)

    D. N. Kirk and M. S. Rajagopalan, J. Chem. Soc., Perkin Trans. 1, 1975, 1860
    DOI: 10.1039/P19750001860

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