Issue 18, 1975
From the journal:

Journal of the Chemical Society, Perkin Transactions 1

Studies on the syntheses of heterocyclic compounds. Part DCXXII. Total synthesis of (±)-mappicine [7-(1-hydroxypropyl)-8-methyl-indolizino[1,2-b]quinolin-9(11H)-one]

Tetsuji Kametani,   Hiromitsu Takeda,   Hideo Nemoto  and  Keiichiro Fukumoto  

Abstract

Methyl 9,11-dihydro-9-oxoindolizino[1,2-b]quinoline-7-carboxylate (4) was converted into its 8-methyl derivative (5), reduction of which gave 7-hydroxymethyl-8-methylindolizino[1,2-b]quinolin-9(11H)-one (9). This was converted into (±)-mappicine (1) by way of the 7-carbaldehyde (13) and the 7-propionyl derivative (14).

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Article information

DOI
https://doi.org/10.1039/P19750001825
Article type
Paper

J. Chem. Soc., Perkin Trans. 1, 1975, 1825-1828

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Studies on the syntheses of heterocyclic compounds. Part DCXXII. Total synthesis of (±)-mappicine [7-(1-hydroxypropyl)-8-methyl-indolizino[1,2-b]quinolin-9(11H)-one]

T. Kametani, H. Takeda, H. Nemoto and K. Fukumoto, J. Chem. Soc., Perkin Trans. 1, 1975, 1825 DOI: 10.1039/P19750001825

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