A series of substituted benzazocine acids (VIa–h) have been prepared by a one-carbon homologation procedure from the benzazocine-2,6-diones (IIa–f). A novel rearrangement of the intermediate aldehyde (Va) to 3,4-dihydrocarbazol-1(2H)-one was discovered. The anti-inflammatory activity of the acids (VIa–h) was investigated.
G. Jones and G. T. Tringham, J. Chem. Soc., Perkin Trans. 1, 1975, 1280 DOI: 10.1039/P19750001280
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