Studies concerning the antibiotic actinonin. Part V. Synthesis of structural analogues of actinonin by the anhydride–ester method

Abstract

The anhydride–ester method for the synthesis of structural analogues (III) of the antibiotic actinonin (I) is described. This route involves reaction between the amino-amides (IV) and the anhydrides (V), giving the acids (VI; R⁵= H); their methyl esters (VI; R⁵= Me) with methanolic alkaline hydroxylamine give the structural analogues (III). The structural analogues (IX) and (X) have been synthesised by a similar route.