Purine studies. Part XIV. Trifluoroacetyl and formyl derivatives of 4,5-diamino-6-methyl-2-methylthiopyrimidine, their ethylation products, and derived purines

Abstract

The acylation products from 4,5-diamino- and 5-amino-4-ethylamino-derivatives of 6-methyl-2-methylthiopyrimidine obtained by using trifluoroacetylating agents have been compared with those obtained by using acetylating and formylating agents. The site of N-ethylation of the trifluoroacetyl derivatives is in some cases different from that in the corresponding acetyl and formyl analogues. The disparity in reactivity is related to the higher lability of the trifluoroacetyl group than of the acetyl and formyl groups. Conversion of the acyl derivatives into the respective purines is described.