Synthesis of the pentapeptide sequence 105–109 and smaller fragments of human encephalitogenic protein containing the arginine residue 107

Abstract

Peptides corresponding to part or all of sequence 105–109 of human encephalitogenic protein, and containing the arginine residue 107, have been synthesized. The peptides were inactive as substrates for the enzyme which methylates arginine-107 in the protein, suggesting a high structural specificity for this enzyme.