Azabenzocycloheptenones. Part XVII. Some substitution reactions in tetrahydro-1-benzazepin-5-ones

Abstract

1,2,3,4-Tetrahydro-1-p-tolylsulphonyl-1-benzazepin-5-ones have been detosylated by two methods. N-Alkylation of 1,2,3,4-tetrahydro-1-benzazepin-5-one and 2,3-dihydro-1H-1-benzazepine with several reagents is reported. Substitution of the 4- and 5-positions of 1,2,3,4-tetrahydro-1-p-tolylsulphonyl-1-benzazepin-5-one has been studied and several transformation products are described. Dehydrogenation of 5,6-dihydrodibenz[b,e]-azepin-11-ones has been re-examined: the products are dibenz[b,c]azepin-11-ones.