Synthesis of 3,6-dihydro-2H-pyrans and pent-2-ene-1,5-diols from αβ-unsaturated ketones via cyclopropyl epoxides
Abstract
Cyclopropyl epoxides, formed directly from αβ-unsaturated ketones by reaction with dimethyloxosulphonium methylide or, better, from cyclopropyl ketones by reaction with dimethylsulphonium methylide, are converted, under acidic conditions, into pent-2-ene-1,5-diols and 3,6-dihydro-2H-pyrans.