Steroids and related studies. Part XXV. Chandonium iodide (17a-methyl-3β-pyrrolidino-17a-aza-D-homoandrost-5-ene dimethiodide) and other quaternary ammonium steroid analogues

Abstract

The bisquaternary analogues 17a-methyl-3β-pyrrolidino-17a-aza-D-homoandrost-5-ene dimethiodide (chandonium iodide)(1)(HS-310) and 4-methyl-17β-dimethylamino-4-aza-5α-androstane dimethiodide (2)(HS-467) and some monoquaternary 17a-aza-D-homo- and 4-aza-androstane derivatives have been prepared. Chandonium iodide is a powerful non-depolarising neuromuscular-blocking agent of short duration and rapid onset, and HS-467 also possessses a marked activity.