Issue 0, 1974

Use of carbohydrate derivatives for studies of phosphorus stereochemistry. Part III. Stereochemical course of nucleophilic displacements of 2-substituents in 1,3,2-dioxaphosphorinan-2-ones and related compounds

Abstract

The stereochemistry of displacement of 2-substituents from 1,3,2-dioxaphosphorinan-2-ones, 1,3,2-oxathiaphosphorinan-2-ones, and 1,3,2-dioxaphosphorinan-2-thiones has been shown to depend on the nature of both the entering and the leaving group. Inversion of configuration has been observed for reactions involving good leaving groups and weak nucleophiles whereas with less good leaving groups and stronger nucleophiles the displacement reactions proceed with retention of configuration.

Article information

Article type
Paper

J. Chem. Soc., Perkin Trans. 1, 1974, 1053-1057

Use of carbohydrate derivatives for studies of phosphorus stereochemistry. Part III. Stereochemical course of nucleophilic displacements of 2-substituents in 1,3,2-dioxaphosphorinan-2-ones and related compounds

J. M. Harrison, T. D. Inch and G. J. Lewis, J. Chem. Soc., Perkin Trans. 1, 1974, 1053 DOI: 10.1039/P19740001053

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