N(3)-Substituted hydantoins bearing a variety of substituents at position 5 have been N(1)-alkylated at room temperature by treatment with several types of alkyl halide or tosylate in anhydrous NN-dimethylformamide containing sodium hydride. The method shows a wide applicability, giving good yields with or without activating groups at position 5.
O. O. Orazi, R. A. Corral and H. Schuttenberg, J. Chem. Soc., Perkin Trans. 1, 1974, 219 DOI: 10.1039/P19740000219
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