Thermodynamic considerations in co-ordination. Part XVI. Formation constants for the cyclopentylamine– and cyclohexylamine–proton, cobalt(II), nickel(II), copper(II), and zinc(II) systems

Abstract

Glass electrode potentiometric studies at 37 °C, I= 150 mM(Na)ClO₄ have been used to study cyclopentylamine-(pent) and cyclohexylamine(hex)–proton–metal²⁺ ion systems. The β values for complex formation obey the Irving–Williams series, are considerably higher than those of comparable ammonia complexes, and have the general order pent > hex > NH₃. A computer model calculation was used to establish that the concentrations of Ni²⁺ mono and bis complexes present at equilibrium qualitatively follow the pattern of carcinostatic activity of their analogous Pt²⁺ complexes.