A general approach to the synthesis of strigol (1) analogues has been developed which involves the stereospecific coupling of bromobutenolides (3a) and (3b) with the sodium enolate (2) of 3-(hydroxymethylene)dihydrofuran-2(3H)-one to give dilactones (4a) and (4b) one of which showed significant cytotoxicity against Hela cells in preliminary testing to evaluate the potential anticancer activity of strigol analogues.
J. M. Cassady and G. A. Howie, J. Chem. Soc., Chem. Commun., 1974, 512 DOI: 10.1039/C39740000512
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