Synthesis and stereochemistry of bis-(3,4-disubstituted 5-oxo-2,5-dihydrofuran-2-yl) ethers
Abstract
Dehydration of 3,4-disubstituted 5-hydroxyfuran-2(5H)-ones by sulphuric acid or thionyl chloride gave the recemic and meso isomers of the corresponding ethers, bis-(3,4-disubstituted 5-oxo-2,5-dihydrofuran-2-yl) ethers. The stereochemistry of the diastereoisomers has been studied by i.r., u.v., and n.m.r. spectroscopy.