Insulin peptides. Part XXIII. The synthesis of a hexadecapeptide derivative related to the B chain of human insulin

Abstract

A protected hexadecapeptide with the amino-acid sequence found at the C-terminal region of the human insulin B chain has been prepared by condensation of N-terminal hexapeptide and C-terminal decapeptide fragments, which were prepared stepwise. All the protecting groups employed are labile to hydrogen fluoride.