Application of the principles of synthesis design to the problem of prostaglandins led to many possible routes, including one commencing with endo-dicyclopentadiene. This starting material was then converted into racemic prostaglandin F2α in a minimum often stages via bicyclo[3.3.0]octane intermediates.
D. Brewster, M. Myers, J. Ormerod, P. Otter, A. C. B. Smith, M. E. Spinner and S. Turner, J. Chem. Soc., Perkin Trans. 1, 1973, 2796 DOI: 10.1039/P19730002796
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