Amino-acids and peptides. Part XIV. Modification of peptides by amino-acid insertion
Abstract
Amide bonds in peptide derivatives have been silylated with chloro(trimethyl)silane and the products have been acylated readily to form N-acyl peptides. Deprotection of the derivatives of N-α- or -β-aminoacyl peptides so formed was followed by rearrangement, with incorporation of the aminoacyl residue into the peptide chain. The inserted optically active amino-acid residues were not racemised.