SCHEDULED MAINTENANCE
Methods for the preparation of various 11 (12)-enol derivatives of steroidal 9α-fluoro-11-ketones are described. The reaction of metal enolates with perchloryl fluorides provides a convenient route to α-fluoro-ketones. Factors permitting control of the direction of enolisation of steroidal 11-ketones are defined. The synthesis of 12α- and 12β-monofluoro- and 12,12-difluoro-9α-fluoro-corticoids is reported.
D. H. R. Barton, R. H. Hesse, M. M. Pechet and T. J. Tewson, J. Chem. Soc., Perkin Trans. 1, 1973, 2365 DOI: 10.1039/P19730002365
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