Issue 0, 1973

Preparation of substituted furan- and thiophen-2-carbaldehydes and -2-[2H]carbaldehydes, and of 2-furyl ketones

Abstract

A series of heterocyclic 2-carbaldehydes and 2-[2H]carbaldehydes have been prepared, most of them by Vilsmeier formylation of mono- and di-substituted furans and thiophens. Isopropylation of methyl furan-2-carboxylate was used to obtain the 4- and 5-monoisopropyl- and 4,5-di-isopropyl-furan-2-carboxylic acids. With different aryl 2-furyl ketones bromine may attack either the benzenoid ring or the heterocyclic ring preferentially.

Article information

Article type
Paper

J. Chem. Soc., Perkin Trans. 1, 1973, 2327-2332

Preparation of substituted furan- and thiophen-2-carbaldehydes and -2-[2H]carbaldehydes, and of 2-furyl ketones

D. J. Chadwick, J. Chambers, H. E. Hargraves, G. D. Meakins and R. L. Snowden, J. Chem. Soc., Perkin Trans. 1, 1973, 2327 DOI: 10.1039/P19730002327

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