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Issue 0, 1973
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Microbiological hydroxylation of steroids. Part IX. Hydroxylation of diketones and keto-alcohols derived from 5α-androstane with the fungi Rhizopus arrhizus and Rhizopus circinnans. Steroidal 18- and 19-proton magnetic resonance signals

Abstract

The hydroxylations of seven diketones and keto-alcohols derived from 5α-androstane with Rhizopus arrhizus and Rhizopus circinnans are similar to, but not identical with, those observed previously using Rhizopus nigricans. R. circinnans is useful for introducing a 4α-hydroxy-group into 5α-androstane-11,17-dione.

N.m.r. shift values are given for the influence on steroidal 18- and 19-H signals of various single substituents, and of systems containing two or more substituents whose effects are not additive.

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Article type: Paper
DOI: 10.1039/P19730002131
J. Chem. Soc., Perkin Trans. 1, 1973, 2131-2136

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    Microbiological hydroxylation of steroids. Part IX. Hydroxylation of diketones and keto-alcohols derived from 5α-androstane with the fungi Rhizopus arrhizus and Rhizopus circinnans. Steroidal 18- and 19-proton magnetic resonance signals

    A. M. Bell, I. M. Clark, W. A. Denny, E. R. H. Jones, G. D. Meakins, W. E. Müller and E. E. Richards, J. Chem. Soc., Perkin Trans. 1, 1973, 2131
    DOI: 10.1039/P19730002131

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