Analysis of structural characteristics of chemical compounds in a large computer-based file. Part V. More detailed cyclic fragments

Abstract

The immediate structural environments of six-membered rings in a sample of chemical compounds taken from the Chemical Abstracts Registry System were studied. Two levels of description were used, the first indicating bonds attached immediately to six-membered rings, the second also including connected atoms. Disparate distributions similar to those identified for rings of different sizes and compositions were noted. The progression to more detailed levels of description did not lead to even resolution of the most frequent ring types.