Stereochemical studies on aromatic α-alkyl-α-amino-acids. Part III. Absolute configuration of 2-amino-2-phenylbutyric acid
Abstract
(+)-2-Formamido-2-phenylbutyric acid has been converted into (–)-2-phenyl-2-p-tolylsulphonylaminobutane, which was also obtained by to sylation of (-)–(S)-2-amino-2-phenylbutane. This correlation proves the S-configuration of (+)-2-amino-2-phenylbutyric acid. Application of stereochemical optical rotation shift rules confirms this assignment.