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Issue 0, 1973
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The megalomicins. Part IV. The structures of megalomicins A, B, C1, and C2

Abstract

The elucidation of the structures and absolute stereochemistry of megalomicins A, B, C1, and C2, a group of macrolide antibiotics elaborated by Micromonospora megalomicea sp. n., is described. Megalomicin A has been shown to be (2R,3S,4S,5R,6R,8R,10R 11R,12S,13R)-3-(2,6-dideoxy-3-C-methyl-α-L-ribo-hexopyranosyloxy)-6,12-di-hydroxy-4,6,8,10,12-hexamethyl-9-oxo-11-(2,3,6-trideoxy-3-dimethylalmino-β-D-lyxo-hexopyranosyloxy)-5-(3,4,6-trideoxy-3-dimethylamino-β-D-xylo- hexopyranosyloxy)pentadecan-13-olide. Megalomicins B, C1, and C2 have been shown to be derivatives of megalomicin A acylated in the 3-glycosyl system.

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Article type: Paper
DOI: 10.1039/P19730001374
J. Chem. Soc., Perkin Trans. 1, 1973, 1374-1388

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    The megalomicins. Part IV. The structures of megalomicins A, B, C1, and C2

    R. S. Jaret, A. K. Mallams and H. Reimann, J. Chem. Soc., Perkin Trans. 1, 1973, 1374
    DOI: 10.1039/P19730001374

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