The synthesis, from 3-propionylthiophen, of the 3-thienyl analogues of ephedrine and ψ-ephedrine, and the resolution of the latter are described. An account is also given of alternative approaches to these isosteres from 2,5-dichloro- and 2,5-dibromo-3-propionylthiophen.
J. M. Barker and P. R. Huddleston, J. Chem. Soc., Perkin Trans. 1, 1973, 1200 DOI: 10.1039/P19730001200
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