SCHEDULED MAINTENANCE
The use of dicyclohexylcarbodi-imide to form peptide bonds in the presence of trifluoroacetate anion can cause substantial trifluoroacetylation of the amino-component. The addition of 1-hydroxybenzotriazole greatly reduces or eliminates this side-reaction.
G. A. Fletcher, M. Löw and G. T. Young, J. Chem. Soc., Perkin Trans. 1, 1973, 1162 DOI: 10.1039/P19730001162
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