Convenient preparations of deuterium-substituted furan-, thiophen-, and N-methylpyrrole-2-carboxylic acids, and of tetradeuteriofuran
Abstract
Deuterium-substituted furan-, thiophen-, and N-methylpyrrole-2-carboxylic acids are conveniently prepared by heating the corresponding protio-acids with sodium deuterioxide in deuterium oxide; the 3,4,5-trideuteriofuran-2-carboxylic acid so obtained is readily converted into tetradeuteriofuran.