Synthesis of 3,9-dimethyl- and 3-methyl-9-ethyl-adenine via N′-alkoxy-1-alkyl-5-formamidoimidazole-4-carboxamidine
Abstract
3,9-Dimethyl- and 3-methyl-9-ethyl-adenine have been synthesized from N′-alkoxy-1-alkyl-5-formamidoimidazole-4-carboxamidine (II) by reduction with LiAIH4 followed by cyclisation with ethyl orthoformate and removal of the alkoxy-group by catalytic hydrogenolysis.