The fluore-9-methanol esters of the 5′-phosphates of oligonucleotides are soluble in organic solvents, and the protected oligonucleotides can be isolated by solvent extraction from the reaction mixture.
N. Katagiri, C. P. Bahl, K. Itakura, J. Michniewicz and S. A. Narang, J. Chem. Soc., Chem. Commun., 1973, 803 DOI: 10.1039/C39730000803
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