Homolytic acylation of protonated pyridine and pyrazine derivatives

Abstract

The results of the homolytic acylation of compounds containing pyridine and pyrazine rings are reported, aldehydes being used as source of acyl radicals. The reactions proceed in high yields and with complete selectivity at positions α and γ to a heterocyclic nitrogen atom. The factors affecting mono- and poly-substitution and the formation of 9-acyl-9,10-dihydro-derivatives with acridine are discussed. A new process of homolytic acylation, based on decarboxylation of α-keto-acids, is also reported.