The kinetics and mechanism of the electrophilic substitution of heteroaromatic compounds. Part XXX. The orientation of the nitration of 2-pyridones
Abstract
The nitration of 2-pyridone yields largely the 3-nitro-derivative in low acidity media and largely the 5-nitro-compound in high acidity media. However, both reactions occur on the free base species. This behaviour is compared with similar phenomena in the literature.